Scaffolds for Guided Bone Tissue Engineering by Wet-Spinning Technique
Abstract
In this project, three dimensional (3D) scaffolds based on polycaprolactone (PCL) and nano-hydroxyapatite (nHA), of different compositions were manufactured by wet-spinning technique. The initially prepared scaffolds were characterized based on their morphological, chemical and mechanical properties by using Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR-ATR), Electron Dispersive Spectroscopy (EDS) and compression test. The optimal scaffold composition found from this characterisation undergoes further functionalisation by employing the layer-by-layer (LBL) assembly. From the different types of analysis performed, it was found that the addition of nano-HA have greatly influenced the mechanical properties and surface morphology of the scaffolds. Morphological studies using SEM provided a clear view of the distribution and settlement of nano-HA within the polymeric fibres. The structure of the scaffold and the addition of nHA particles have affected the strength and elastic modulus of the scaffolds, which has been determined by mechanical characterization. FTIR-ATR analysis provided a similar spectra for both PCL and PCL/nHA scaffolds. The obtained results suggested that, in the field of guided bone tissue regeneration, PCL/nHA scaffolds can have a good application.
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